标题：The role of galectin-4 in physiology and diseases
作者：Cao, Zhan-Qi; Guo, Xiu-Li
作者机构：[Cao Zhanqi] Department of Pharmacology, School of Pharmaceutical Sciences, Shandong University, Ji'nan, Shandong 50012, China.;[Guo Xiuli] Department 更多
通讯作者地址：[Guo, XL]Shandong Univ, Sch Pharmaceut Sci, Dept Pharmacol, Jinan 50012, Peoples R China.
关键词：galectin-4; lipid raft; crosslinker; intestinal inflammation; tumor; progression
摘要：Galectin-4, a tandem repeat member of the beta-galactoside-binding proteins, possesses two carbohydrate-recognition domains (CRD) in a single peptide chain. This lectin is mostly expressed in epithelial cells of the intestinal tract and secreted to the extracellular. The two domains have 40% similarity in amino acid sequence, but distinctly binding to various ligands. Just because the two domains bind to different ligands simultaneously, galectin-4 can be a crosslinker and crucial regulator in a large number of biological processes. Recent evidence shows that galectin-4 plays an important role in lipid raft stabilization, protein apical trafficking, cell adhesion, wound healing, intestinal inflammation, tumor progression, etc. This article reviews the physiological and pathological features of galectin-4 and its important role in such processes.