标题:The role of galectin-4 in physiology and diseases
作者:Cao, Zhan-Qi; Guo, Xiu-Li
作者机构:[Cao Zhanqi] Department of Pharmacology, School of Pharmaceutical Sciences, Shandong University, Ji'nan, Shandong 50012, China.;[Guo Xiuli] Department 更多
通讯作者:Guo, XL(guoxl@sdu.edu.cn)
通讯作者地址:[Guo, XL]Shandong Univ, Sch Pharmaceut Sci, Dept Pharmacol, Jinan 50012, Peoples R China.
来源:蛋白质与细胞
出版年:2016
卷:7
期:5
页码:314-324
DOI:10.1007/s13238-016-0262-9
关键词:galectin-4; lipid raft; crosslinker; intestinal inflammation; tumor; progression
摘要:Galectin-4, a tandem repeat member of the beta-galactoside-binding proteins, possesses two carbohydrate-recognition domains (CRD) in a single peptide chain. This lectin is mostly expressed in epithelial cells of the intestinal tract and secreted to the extracellular. The two domains have 40% similarity in amino acid sequence, but distinctly binding to various ligands. Just because the two domains bind to different ligands simultaneously, galectin-4 can be a crosslinker and crucial regulator in a large number of biological processes. Recent evidence shows that galectin-4 plays an important role in lipid raft stabilization, protein apical trafficking, cell adhesion, wound healing, intestinal inflammation, tumor progression, etc. This article reviews the physiological and pathological features of galectin-4 and its important role in such processes.
收录类别:CSCD;SCOPUS;SCIE
WOS核心被引频次:8
Scopus被引频次:7
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-84961615891&doi=10.1007%2fs13238-016-0262-9&partnerID=40&md5=0886dea9a334496c064278a00d44891e
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