标题：Ovarian serous carcinogenesis from tubal secretory cells
作者：Zhang, Wenjing; Wei, Linxuan; Li, Lingmin; Yang, Binlie; Kong, Beihua; Yao, Guang; Zheng, Wenxin
作者机构：[Zhang, Wenjing; Wei, Linxuan; Li, Lingmin; Yang, Binlie; Zheng, Wenxin] Univ Arizona, Coll Med, Dept Pathol, Tucson, AZ 85721 USA.; [Zhang, Wenjing 更多
通讯作者地址：[Yao, G]Univ Arizona, Mol & Cellular Biol, 1007 E Lowell St, Tucson, AZ 85721 USA.
来源：HISTOLOGY AND HISTOPATHOLOGY
关键词：Ovarian serous carcinoma; Secretory cell; Fallopian tube; LGSC; HGSC
摘要：Due to a poor understanding of tumorigenesis, ovarian cancers remain the most lethal gynecologic malignancy and cause horrific deaths. In the last decade, a new dualistic model for ovarian cancer was proposed, wherein ovarian serous cancers are classified as either high-grade or low-grade, with each having different tumorigenic processes, and pathologic and clinical features. Surprisingly, both high- and low-grade ovarian serous cancers were recently found to originate not in the ovaries, but rather from the secretory cells of the fallopian tube, mostly from the tubal fimbriated ends. In this article, we review the evidentiary basis for the aforementioned paradigm shift in the cell origin of ovarian serous cancers, as well as its potential clinical implications.