标题：Is antioxidant supplement beneficial? New avenue to explore
作者：Shen, Liang; Ji, Hong-Fang
作者机构：[Shen, Liang; Ji, Hong-Fang] Shandong Univ Technol, Sch Life Sci, Shandong Prov Res Ctr Bioinformat Engn & Tech, Zibo 255049, Peoples R China.
通讯作者地址：[Ji, HF]Shandong Univ Technol, Sch Life Sci, Shandong Prov Res Ctr Bioinformat Engn & Tech, Zibo 255049, Peoples R China.
来源：TRENDS IN FOOD SCIENCE & TECHNOLOGY
关键词：Antioxidant; Oxidative stress; Nitrosative stress; Sensor; Probe
摘要：Background: In recent years, numerous disappointing clinical outcomes of antioxidant supplement have been reported for various oxidative and nitrosative stress-related diseases. These failures of antioxidant supplement in preventing/treating diseases have become a major hurdle in the therapeutic application.; Scope and approach: This paper described the current status of antioxidant supplement area, and reviewed briefly the important progress in developing probes or sensors for real-time imaging of reactive oxygen species (ROS) and reactive nitrogen species (RNS) in recent years. We then explored the potential of these probes or sensors for real-time imaging of ROS and RNS as new avenues to directly assess whether antioxidants work or not in vivo.; Key findings and conclusions: Examining whether or not antioxidant can counteract oxidative and nitrosative stress in vivo is crucial to overcome the hurdles in the antioxidant supplement area. We proposed that the recently developed probes or sensors for real-time imaging of ROS and RNS provided a valuable avenue to assess the antioxidant efficacy in vivo. Future directions and potential barriers to overcome for clinical translations of these probes or sensors were discussed to direct antioxidant supplement study. (C) 2017 Elsevier Ltd. All rights reserved.