标题：miRNA dysregulation and the risk of metastasis and invasion in papillary thyroid cancer: a systematic review and meta-analysis
作者：Wang, Tiantian; Xu, Hao; Qi, Ming; Yan, Sheng; Tian, Xingsong
作者机构：[Wang, Tiantian; Xu, Hao; Qi, Ming; Tian, Xingsong] Shandong Univ, Dept Breast & Thyroid Surg, Shandong Prov Hosp, Jinan, Shandong, Peoples R China.; 更多
通讯作者：Tian, XS;Yan, S
通讯作者地址：[Tian, XS]Shandong Univ, Dept Breast & Thyroid Surg, Shandong Prov Hosp, Jinan, Shandong, Peoples R China;[Yan, S]Sun Yat Sen Univ, Hosp 1, Dept Neuro 更多
关键词：miRNA; invasive thyroid cancer; metastasis; meta-analysis
摘要：Thyroid cancer (TC) is the most common endocrine malignancy, with an incidence continuing to grow every year. Although thyroid cancer as a whole is generally indolent and relatively easy to treat, some subtypes carry a higher rate of metastasis and cancer-related mortality. A growing number of studies have focused on the dysregulation of miRNAs in TC. However, differences in methods make comparison of gene profiling data difficult. A meta-analysis of published studies comparing miRNA expression data of invasive thyroid carcinoma with paired non-invasive tumors or normal tissues was performed by searching the literature for "invasion", "thyroid cancer", and "miRNA". This revealed 29 dysregulated miRNAs associated with TC in 16 articles; the presence of invasion was confirmed in each respective article by laboratory research or patient follow-up. Among these miRNAs, miRNA-146b, miRNA-221, and miRNA-222 were analyzed further due to their higher frequencies across multiple studies. Of these studies, 6 were included in the meta-analysis, as they compared invasive PTC with paired normal tissues or non-invasive PTC.