标题:miRNA dysregulation and the risk of metastasis and invasion in papillary thyroid cancer: a systematic review and meta-analysis
作者:Wang, Tiantian; Xu, Hao; Qi, Ming; Yan, Sheng; Tian, Xingsong
作者机构:[Wang, Tiantian; Xu, Hao; Qi, Ming; Tian, Xingsong] Shandong Univ, Dept Breast & Thyroid Surg, Shandong Prov Hosp, Jinan, Shandong, Peoples R China.; 更多
通讯作者:Tian, XS;Yan, S
通讯作者地址:[Tian, XS]Shandong Univ, Dept Breast & Thyroid Surg, Shandong Prov Hosp, Jinan, Shandong, Peoples R China;[Yan, S]Sun Yat Sen Univ, Hosp 1, Dept Neuro 更多
来源:ONCOTARGET
出版年:2018
卷:9
期:4
页码:5473-5479
DOI:10.18632/oncotarget.16681
关键词:miRNA; invasive thyroid cancer; metastasis; meta-analysis
摘要:Thyroid cancer (TC) is the most common endocrine malignancy, with an incidence continuing to grow every year. Although thyroid cancer as a whole is generally indolent and relatively easy to treat, some subtypes carry a higher rate of metastasis and cancer-related mortality. A growing number of studies have focused on the dysregulation of miRNAs in TC. However, differences in methods make comparison of gene profiling data difficult. A meta-analysis of published studies comparing miRNA expression data of invasive thyroid carcinoma with paired non-invasive tumors or normal tissues was performed by searching the literature for "invasion", "thyroid cancer", and "miRNA". This revealed 29 dysregulated miRNAs associated with TC in 16 articles; the presence of invasion was confirmed in each respective article by laboratory research or patient follow-up. Among these miRNAs, miRNA-146b, miRNA-221, and miRNA-222 were analyzed further due to their higher frequencies across multiple studies. Of these studies, 6 were included in the meta-analysis, as they compared invasive PTC with paired normal tissues or non-invasive PTC.
收录类别:SCOPUS;SCIE
Scopus被引频次:3
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-85040466720&doi=10.18632%2foncotarget.16681&partnerID=40&md5=d9076f8a683d3ee833587781467b8029
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