标题:Cross-dehydrogenative coupling of secondary benzylic ethers with indoles and pyrroles
作者:Cao, Min; Mao, Ying; Huang, Jiancheng; Ma, Yudao; Liu, Lei
作者机构:[Cao, Min; Huang, Jiancheng; Ma, Yudao; Liu, Lei] Shandong Univ, Sch Chem & Chem Engn, Jinan 250100, Shandong, Peoples R China.; [Mao, Ying; Liu, Le 更多
通讯作者:Ma, YD;Liu, L
通讯作者地址:[Ma, YD; Liu, L]Shandong Univ, Sch Chem & Chem Engn, Jinan 250100, Shandong, Peoples R China.
来源:TETRAHEDRON LETTERS
出版年:2019
卷:60
期:15
页码:1075-1078
DOI:10.1016/j.tetlet.2019.03.032
关键词:Cross-dehydrogenative coupling; Secondary benzylic ether; Indole;; Quaternary center
摘要:Current studies on cross-dehydrogenative coupling of benzylic ethers for new C-C bond construction predominantly focus on primary ether moieties. Oxidative cross-coupling of secondary benzylic ethers remains elusive. Herein, we describe the first cross-dehydrogenative coupling of secondary benzylic ethers with indoles and pyrroles for tertiary ether construction. A broad range of alpha-aryl substituted isochromans react with a variety of electronically varied indoles and pyrroles smoothly under mild metal-free conditions in high efficiency. In addition, the catalytic asymmetric variant was preliminarily explored, and corresponding tertiary ether was obtained in 69% ee. (C) 2019 Elsevier Ltd. All rights reserved.
收录类别:SCOPUS;SCIE
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-85062922013&doi=10.1016%2fj.tetlet.2019.03.032&partnerID=40&md5=a8f12f7a562e0e9fb14d99c330208f38
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