标题:Enhanced cancer cell killing by a targeting gold nanoconstruct with doxorubicin payload under X-ray irradiation
作者:Zhou, Hongyu; Zhang, Yi; Su, Gaoxing; Zhai, Shumei; Yan, Bing
作者机构:[Zhou, Hongyu; Zhang, Yi; Su, Gaoxing; Zhai, Shumei; Yan, Bing] Shandong Univ, Sch Chem & Chem Engn, Jinan 250100, Peoples R China.
通讯作者:Yan, B
通讯作者地址:[Yan, B]Shandong Univ, Sch Chem & Chem Engn, Jinan 250100, Peoples R China.
来源:RSC ADVANCES
出版年:2013
卷:3
期:44
页码:21596-21603
DOI:10.1039/c3ra43838d
摘要:In this report, a cancer-targeting nanoconstruct enters a cancer cell four times more readily than non-targeting nanoparticles. Inside the cell, the nanoconstruct conducts a double DNA attack from a DNA intercalating drug doxorubicin and radiation-enhancing gold nanoparticles achieving 2.5 fold higher DNA double strand breakage in the cancer genome. An overall 4.0 or 2.7-fold increase in cancer cell killing was achieved compared to the free drug without or with X-ray irradiation and a significant reduction in nonspecific toxicity to folate receptor-negative cells demonstrated the unique advantage of a nanomedicine approach to future chemotherapy and radiotherapy.
收录类别:EI;SCOPUS;SCIE
WOS核心被引频次:4
Scopus被引频次:4
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-84886540339&doi=10.1039%2fc3ra43838d&partnerID=40&md5=9e8df28d9e8a3ac7025028b7ced4f328
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