标题：Presarcopenia Is an Independent Risk Factor for Carotid Atherosclerosis in Chinese Population with Metabolic Syndrome
作者：Cao, Yuan; Zhong, Ming; Zhang, Yuke; Zheng, Zijie; Liu, Yapeng; Ni, Xiaoning; Han, Lu; Song, Ming; Zhang, Wei; Wang, Zhihao
作者机构：[Cao, Yuan; Zhong, Ming; Zheng, Zijie; Liu, Yapeng; Ni, Xiaoning; Han, Lu; Song, Ming; Zhang, Wei; Wang, Zhihao] Shandong Univ, Key Lab Cardiovasc Rem 更多
通讯作者：Zhang, W;Wang, ZH;Zhang, W;Wang, ZH;Zhang, W;Wang, ZH;Wang, ZH
通讯作者地址：[Zhang, W; Wang, ZH]Shandong Univ, Key Lab Cardiovasc Remodeling & Funct Res, Chinese Minist Educ, Chinese Natl Hlth Commiss, 107 Wen Hua Xi Rd, Jinan 更多
来源：DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
关键词：skeletal muscle mass; presarcopenia; metabolic syndrome; carotid; atherosclerosis
摘要：Purpose: To investigate the impacts of skeletal muscle mass on carotid atherosclerosis in Chinese adults with metabolic syndrome (MetS).; Methods: One hundred and ninety-five subjects with MetS had the waist-to-height ratio (WHTR)=0.5 for all. One hundred and eighty-four subjects without MetS were divided into 2 groups: Non-Mets obese group (WHTR = 0.5, n = 118) and Non-MetS control group (WHTR < 0.5, n = 66). All the groups had no difference in age. Appendicular skeletal muscle mass was acquired and skeletal muscle mass index (SMI) was calculated. Carotid intima-media thickness (IMT) was assessed by ultrasonography. Each group was stratified according to the presence or absence of presarcopenia.; Results: While most parameters showed an increasing trend with WHTR and MetS in both genders, SMI and HDL-C showed a decreasing trend. The prevalence of carotid atherosclerosis showed the same increasing trend. Multivariate logistic regression analyses showed SBP and presarcopenia were both independent risk factors for carotid atherosclerosis in MetS (OR 1.026, P < 0.001; OR 2.788, P = 0.001, respectively). There was no significant difference in IMT among the three groups with preserved muscle mass whether the participants suffered from obesity or MetS, while there was a significant difference between the two groups with presarcopenia (in male P = 0.020, in female P = 0.009, respectively). The area under the ROC curve (AUC) was 0.641 (P<0.001) for presarcopenia.; Conclusion: Obesity was a risk factor for sarcopenia independent of age, especially in subjects with metabolic syndrome. In individuals with MetS, our findings suggest that presarcopenia may be an independent risk factor for atherosclerosis and appendicular skeletal muscle mass had potential protective effects for carotid atherosclerosis regardless of gender.