标题:Upregulation of B7-H1 expression is associated with macrophage infiltration in hepatocellular carcinomas
作者:Chen,J.;Li,G.;Meng,H.;Fan,Y.;Song,Y.;Wang,S.;Zhu,F.;Guo,C.;Zhang,L.;Shi,Y.
作者机构:[Chen, J] Institute of Immunology, School of Medicine, Shandong University, 44# Wenhua Xi Road, Jinan 250012, China;[ Li, G] Institute of Immunology, 更多
通讯作者:Shi, YY
通讯作者地址:[Shi, YY]Shandong Univ, Sch Med, Inst Immunol, 44 Wenhua Xi Rd, Jinan 250012, Peoples R China.
来源:Cancer Immunology and Immunotherapy: Other Biological Response Modifications
出版年:2012
卷:61
期:1
页码:101-108
DOI:10.1007/s00262-011-1094-3
关键词:B7-H1;CD274;Hepatocellular carcinoma;PD-L1;Tumor-associated macrophages
摘要:The overexpression of B7-H1 in hepatocellular carcinoma (HCC) mediates HCC immune escape and obstructs the immunotherapy based on tumor-specific CD8+ T cells. Tumor-associated macrophages (TAM) are a major component of cancer-related inflammation and play a central role in tumor promotion. To classify the mechanism underlying the overexpression of B7-H1 in HCC, we examined B7-H1 expression and TAM infiltration in 63 cases of human HCC samples using immunohistochemistry method and found that B7-H1 overexpression was associated with TAM infiltration in HCC tissues. Furthermore, B7-H1 expression was upregulated at both mRNA level and protein level in HCC cells (BEL-7402 and SMMC-7721) cocultured with macrophages in a transwell system. The upregulation of B7-H1 expression induced by macrophage was inhibited by blocking NF-κB or STAT3 signal pathways. These results suggest that overexpression of B7-H1 in HCC may be induced by inflammatory microenvironment involving macrophages and imply that anti-inflammation therapy might be preventive for immune escape and assistant for immunotherapy of HCC.
收录类别:SCOPUS;SCIE
WOS核心被引频次:36
Scopus被引频次:38
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-84856747778&doi=10.1007%2fs00262-011-1094-3&partnerID=40&md5=fcc966fdeea91f9c0202f581584800c2
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