标题：Sleep problems and risk of all-cause cognitive decline or dementia: an updated systematic review and meta-analysis
作者：Xu, Wei; Tan, Chen-Chen; Zou, Juan-Juan; Cao, Xi-Peng; Tan, Lan
作者机构：[Xu, Wei; Tan, Chen-Chen; Tan, Lan] Qingdao Univ, Qingdao Municipal Hosp Grp, Neurol Dept, Qingdao, Shandong, Peoples R China.; [Zou, Juan-Juan] Sha 更多
通讯作者地址：Xu, W (corresponding author), Qingdao Municipal Hosp Grp, Neurol Dept, Qingdao, Shandong, Peoples R China.
来源：JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
摘要：Objectives To conduct an updated systematic review and meta-analysis of association between sleep and all-cause cognitive disorders.; Methods PubMed and EMBASE were searched from inception to 18 February 2019. Cohort studies exploring longitudinal associations of sleep with cognitive decline or dementia were included. The multivariable-adjusted effect estimates were pooled by random-effects models, with credibility assessment. The robusterror meta-regression model was used to conduct the dose-response meta-analysis for sleep duration.; Results 11 155 reports were searched and 51 eligible cohorts with 15 sleep problems were included for our meta-analyses. Ten types of sleep conditions or parameters, including six (insomnia, fragmentation, daytime dysfunction, prolonged latency, rapid eye movement sleep behaviour disorder and excessive time in bed) with moderate-to-high levels of evidence, were linked to higher risk of all-cause cognitive disorders. Furthermore, a U-shaped relationship was revealed for the associations with sleep duration.; Conclusions Sleep management might serve as a promising target for dementia prevention.