标题：Diabetes mellitus and increased risk of biliary tract cancer: systematic review and meta-analysis.
作者：Ren HB;Yu T;Liu C;Li YQ
作者机构：[Ren, H.-B] Department of Gastroenterology, Shandong University, Qilu Hospital, 107 Wenhua xi Road, Jinan, Shandong Province 250012, China;[ Yu, T] De 更多
通讯作者地址：[Li, YQ]Shandong Univ, Qilu Hosp, Dept Gastroenterol, 107 Wenhua Xi Rd, Jinan 250012, Shandong, Peoples R China.
来源：Cancer causes and control: CCC
关键词：Biliary tract cancer; Diabetes mellitus; Relative risk; Systematic; review; Meta-analysis
摘要：OBJECTIVE: Epidemiological evidences indicate that diabetic individuals may have an increased risk of several cancers; however, the relationships between diabetes and risk of cancers of biliary tract or its subsites remain unclear. METHODS: To provide a quantitative assessment of this relationship, we identified studies by a literature search of Medline (from 1 January 1966) and EMBASE (from 1 January 1974), through 31 July 2010, and by searching the reference lists of pertinent articles. Summary relative risks with corresponding 95% confidence intervals were calculated with a random-effect model. RESULTS: Analysis of 21 studies (8 case-control and 13 cohort studies) found that diabetes was associated with an increased risk of biliary tract cancer, compared with no diabetes (summary RRs = 1.43, 95% CI = 1.18-1.72), with significant heterogeneity among studies (p = 0.001). The positive association was also found between diabetes and risk of gallbladder cancer or extrahepatic cholangiocarcinoma, but not cancer of ampulla of Vater. No significant publication bias was found. CONCLUSION: These findings strongly support the link between diabetes and increased risk of cancer of biliary tract and its subsites: gallbladder cancer or extrahepatic cholangiocarcinoma, but not cancer of ampulla of Vater.