标题:Diabetes mellitus and increased risk of biliary tract cancer: systematic review and meta-analysis.
作者:Ren HB;Yu T;Liu C;Li YQ
作者机构:[Ren, H.-B] Department of Gastroenterology, Shandong University, Qilu Hospital, 107 Wenhua xi Road, Jinan, Shandong Province 250012, China;[ Yu, T] De 更多
通讯作者:Li, YQ
通讯作者地址:[Li, YQ]Shandong Univ, Qilu Hosp, Dept Gastroenterol, 107 Wenhua Xi Rd, Jinan 250012, Shandong, Peoples R China.
来源:Cancer causes and control: CCC
出版年:2011
卷:22
期:6
页码:837-847
DOI:10.1007/s10552-011-9754-3
关键词:Biliary tract cancer; Diabetes mellitus; Relative risk; Systematic; review; Meta-analysis
摘要:OBJECTIVE: Epidemiological evidences indicate that diabetic individuals may have an increased risk of several cancers; however, the relationships between diabetes and risk of cancers of biliary tract or its subsites remain unclear. METHODS: To provide a quantitative assessment of this relationship, we identified studies by a literature search of Medline (from 1 January 1966) and EMBASE (from 1 January 1974), through 31 July 2010, and by searching the reference lists of pertinent articles. Summary relative risks with corresponding 95% confidence intervals were calculated with a random-effect model. RESULTS: Analysis of 21 studies (8 case-control and 13 cohort studies) found that diabetes was associated with an increased risk of biliary tract cancer, compared with no diabetes (summary RRs = 1.43, 95% CI = 1.18-1.72), with significant heterogeneity among studies (p = 0.001). The positive association was also found between diabetes and risk of gallbladder cancer or extrahepatic cholangiocarcinoma, but not cancer of ampulla of Vater. No significant publication bias was found. CONCLUSION: These findings strongly support the link between diabetes and increased risk of cancer of biliary tract and its subsites: gallbladder cancer or extrahepatic cholangiocarcinoma, but not cancer of ampulla of Vater.
收录类别:SCOPUS;SCIE
WOS核心被引频次:43
Scopus被引频次:47
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-79956278750&doi=10.1007%2fs10552-011-9754-3&partnerID=40&md5=99b2da2851046e73dfed2600e9db0192
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