标题:A new diketopiperazine heterodimer from an endophytic fungus Aspergillus niger
作者:Li, Xiao-Bin;Li, Yue-Lan;Zhou, Jin-Chuan;Yuan, Hui-Qing;Wang, Xiao-Ning;Lou, Hong-Xiang
作者机构:Shandong Univ, Sch Pharmaceut Sci, Dept Nat Prod Chem, Key Lab Chem Biol,Minist Educ, Jinan 250012;Shandong Univ, Sch Pharmaceut
来源:Journal of Asian natural products research
出版年:2015
期:1
页码:182-187
关键词:Aspergillus niger;endophytic fungus;alpha-pyrone;cytotoxicity;diketopiperazine heterodimer
摘要:One new diketopiperazine heterodimer, asperazine A (1), and eight known compounds, asperazine (2), cyclo(d-Phe-l-Trp) (3), cyclo(l-Trp-l-Trp) (4), 4-(hydroxymethyl)-5,6-dihydro-pyran-2-one (5), walterolactone A (6), and campyrones A-C (7-9), were isolated from an endophytic fungus Aspergillus niger. Their structures were determined unequivocally on the basis of extensive spectroscopic data analysis. This is the first report of the presence of compound 3 as a natural product. Cytotoxicity test against human cancer cell lines PC3, A2780, K562, MBA-MD-231, and NCI-H1688 revealed that compounds 1 and 2 had weak activities.
资源类型:期刊论文
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