标题：Cyclin F and KIF20A, FOXM1 target genes, increase proliferation and invasion of ovarian cancer cells
作者：Li Y.; Guo H.; Wang Z.; Bu H.; Wang S.; Wang H.; Fang H.; Liu Z.;等
作者机构：[Li, Y] School of Medicine, Cheeloo College of Medicine, Shandong University, Ji'nan, Shandong 250012, China;[ Guo, H] Department of Clinical Laborat 更多
通讯作者地址：[Kong, B] Department of Obstetrics and Gynecology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Department of Cell Biology, Shando 更多
来源：Experimental Cell Research
关键词：Cyclin F; FOXM1; KIF20A; Ovarian cancer
摘要：Increased expression of FOXM1 is observed in a variety of human malignancies. The downstream target genes of FOXM1 involved in tumorigenesis and development are not fully elucidated in ovarian cancer. Here, we identified Cyclin F, a substrate recognition subunit of SCF (Skp1-Cul1-F-box protein) complex, and Kinesin Family Member 20A (KIF20A) were transcriptionally regulated by FOXM1 in ovarian cancer. Accordingly, Cyclin F and KIF20A were commonly overexpressed in ovarian cancer. Functionally, forced expression of Cyclin F or KIF20A significantly enhanced while knockdown of them decreased proliferation and invasion of ovarian cancer cells. Importantly, high levels of Cyclin F and KIF20A correlated with poor prognosis in patients with ovarian cancer. Our findings indicate that Cyclin F and KIF20A are functional targets of FOXM1 which might be potential drug targets in ovarian cancer. © 2020 Elsevier Inc.