标题:Cyclin F and KIF20A, FOXM1 target genes, increase proliferation and invasion of ovarian cancer cells
作者:Li Y.; Guo H.; Wang Z.; Bu H.; Wang S.; Wang H.; Fang H.; Liu Z.;等
作者机构:[Li, Y] School of Medicine, Cheeloo College of Medicine, Shandong University, Ji'nan, Shandong 250012, China;[ Guo, H] Department of Clinical Laborat 更多
通讯作者:Kong, B(kongbeihua@sdu.edu.cn)
通讯作者地址:[Kong, B] Department of Obstetrics and Gynecology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Department of Cell Biology, Shando 更多
来源:Experimental Cell Research
出版年:2020
卷:395
期:2
DOI:10.1016/j.yexcr.2020.112212
关键词:Cyclin F; FOXM1; KIF20A; Ovarian cancer
摘要:Increased expression of FOXM1 is observed in a variety of human malignancies. The downstream target genes of FOXM1 involved in tumorigenesis and development are not fully elucidated in ovarian cancer. Here, we identified Cyclin F, a substrate recognition subunit of SCF (Skp1-Cul1-F-box protein) complex, and Kinesin Family Member 20A (KIF20A) were transcriptionally regulated by FOXM1 in ovarian cancer. Accordingly, Cyclin F and KIF20A were commonly overexpressed in ovarian cancer. Functionally, forced expression of Cyclin F or KIF20A significantly enhanced while knockdown of them decreased proliferation and invasion of ovarian cancer cells. Importantly, high levels of Cyclin F and KIF20A correlated with poor prognosis in patients with ovarian cancer. Our findings indicate that Cyclin F and KIF20A are functional targets of FOXM1 which might be potential drug targets in ovarian cancer. © 2020 Elsevier Inc.
收录类别:SCOPUS
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-85089345420&doi=10.1016%2fj.yexcr.2020.112212&partnerID=40&md5=bc0c8e96c29e6d5031ed03977dd8d157
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