标题:Advances in immunopathogenesis of adult immune thrombocytopenia
作者:Liu, Xinguang; Hou, Yu; Peng, Jun
作者机构:[Liu Xinguang] Department of Hematology, Qilu Hospital, Shandong University, Jinan, Shandong 250012, China.;[Peng Jun] Department of Hematology, Qilu 更多
通讯作者地址:[Peng, J]Shandong Univ, Qilu Hosp, Dept Hematol, Jinan 250012, Peoples R China.
来源:医学前沿
出版年:2013
卷:7
期:4
页码:418-424
DOI:10.1007/s11684-013-0297-8
关键词:primary immune thrombocytopenia;B lymphocytes;T lymphocytes;antigen-presenting cells;cytokines
摘要:Primary immune thrombocytopenia (ITP) is an autoimmune disorder characterized by immune-mediated accelerated platelet destruction and/or suppressed platelet production. Although the development of autoantibodies against platelet glycoproteins remains central in the pathophysiology of ITP, several abnormalities involving the cellular mechanisms of immune modulation have been identified, and the pathways behind the immune-mediated destruction of platelets have opened new avenues for the design of specific immunotherapies in an attempt to reduce the platelet destruction. This review is primarily focused on the recent literature with respect to immunopathological mechanisms in patients with ITP.
收录类别:CSCD;SCIE
WOS核心被引频次:9
资源类型:期刊论文
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