标题:Design, synthesis and biological evaluation of novel non-azole derivatives as potential antifungal agents
作者:Tang, Hui; Wu, Juan; Zhang, Wen; Zhao, Lei; Zhang, Ya-Hui; Shen, Cheng-Wu
作者机构:[Tang, H] Department of Pharmacy, Shandong Provincial Hospital, Shandong University, Jinan, 250021, China;[ Wu, J] Department of Pharmacy, General Hos 更多
通讯作者地址:[Shen, CW]Shandong Univ, Shandong Prov Hosp, Dept Pharm, Jinan 250021, Peoples R China.
来源:中国化学快报(英文版)
出版年:2015
卷:26
期:9
页码:1161-1164
DOI:10.1016/j.cclet.2015.04.030
关键词:Non-azole; Biological evaluation; Structure-activity relationships;; Synthesis; Antifungal agents
摘要:A series of 3-substituted quinazolinones, 2-substituted quinoxalines and 2-substituted benzopyrans were synthesized and evaluated for their antifungal activity in vitro. The new compounds revealed excellent in vitro antifungal activity with broad spectrum. The structure-activity relationships (SARs) of the derivatives were analyzed. Compound 9A2 exhibits better antifungal activity against 5 tested fungi in vitro than fluconazole, especially against Trichophyton rubrum and Microsporum gypseum. This study provides a series of novel lead compounds for the development of non-azole antifungal agents. (C) 2015 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.
收录类别:CSCD;SCOPUS;SCIE
WOS核心被引频次:3
Scopus被引频次:5
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-84940713488&doi=10.1016%2fj.cclet.2015.04.030&partnerID=40&md5=95fbb715efbfe3798b8dc97c65805b18
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