标题：A new chapter: hematopoietic stem cells are direct players in immunity
作者：Zheng, Junke; Song, Chun; Zhang, Cheng Cheng
作者机构：[Zheng, Junke; Zhang, Cheng Cheng] Univ Texas SW Med Ctr Dallas, Dept Physiol, Dallas, TX 75390 USA.; [Zheng, Junke; Zhang, Cheng Cheng] Univ Texas 更多
通讯作者地址：[Zhang, CC]Univ Texas SW Med Ctr Dallas, Dept Physiol, 5323 Harry Hines Blvd, Dallas, TX 75390 USA.
来源：CELL AND BIOSCIENCE
关键词：stem cell; hematopoietic stem cells; immunity; immunology; CD47; CD274;; infection; inflammation; niche
摘要：Several lines of evidence support the hypothesis that hematopoietic stem cells (HSCs) directly interact with the immune system and have potential for immune privilege. Although the microenvironment or niche provides protection for HSCs from immune attack, HSCs are also capable of interacting with the immune system as signal "providers" and signal "receivers". On the one hand, HSCs display surface immune inhibitory molecules to evade the attack from the innate and adaptive immune systems; on the other hand, HSCs are capable of directly sensing the signals from the immune system through their surface receptors. Thus, HSCs are important direct players in the immune system.