标题：Podoplanin: a novel regulator of tumor invasion and metastasis
作者：Dang, Qi; Liu, Jie; Li, Juan; Sun, Yuping
作者机构：[Dang, Qi; Liu, Jie; Sun, Yuping] Shandong Univ, Jinan Cent Hosp, Dept Oncol, Jinan 250100, Shandong, Peoples R China.; [Li, Juan] Shandong Univ, Ji 更多
通讯作者地址：[Sun, YP]Shandong Univ, Jinan Cent Hosp, Dept Oncol, Jinan 250100, Shandong, Peoples R China.
关键词：Podoplanin; Tumor progression; EMT; Collective-cell migration; Platelet; aggregation
摘要：Podoplanin, a small mucin-type sialoglycoprotein, was recently shown to be involved in tumor progression. Podoplanin is overexpressed in cancer cells of various human malignancies, and recently, it is also detected in intratumoral stromal cells. We now appreciate that podoplanin plays a dual role in cancer: it can not only suppress tumor growth but also promote tumor progression. Researchers have identified several potential pathways invoked by podoplanin, which participate in the epithelial-to-mesenchymal transition, collective-cell migration, platelet activation and aggregation, and lymphangiogenesis, and thus regulate the tumor invasion and metastasis. Here, we discuss the current experimental and human clinical data on podoplanin to validate the multiple context-dependent functions in different microenvironments and to delineate the diverse regulatory mechanisms.