标题：Phosphate chemical conversion coatings on metallic substrates for biomedical application: A review
作者：Liu, Bing; Zhang, Xian; Xiao, Gui-yong; Lu, Yu-peng
作者机构：[Liu, Bing; Zhang, Xian; Xiao, Gui-yong; Lu, Yu-peng] Shandong Univ, Suzhou Inst, Suzhou 215123, Peoples R China.; [Liu, Bing; Zhang, Xian; Xiao, Gu 更多
通讯作者地址：[Lu, YP]Shandong Univ, Sch Mat Sci & Engn, Jinan 250061, Peoples R China.
来源：MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
关键词：Phosphate; Conversion coating; Phase; Quality; Biological response
摘要：Phosphate chemical conversion (PCC) technology has been investigated for improving the surface performance of metallic implants in the biomedical field over the last decade. The metallic materials, such as magnesium and its alloys, titanium, pure iron and stainless steel are widely used as orthopedic devices for immobilization of bone fractures in clinic. They were previously studied as metal substrates for PCC coating aiming to modify their biocompatibility and osteoconductivity. Zinc, calcium and zinc-calcium PCC coatings are frequently utilized considering their nature and the end-use. Although PCC coating has been confirmed to potentially improve the bioperformance of metallic implants in vitro and in vivo by many researchers, there are no unified standards or regulations to give quantitative appraisal of its quality and property. As such, an overview of several main phosphate phases together with their properties and behaviors in vitro and in vivo was conducted. The mechanism of phosphating was also briefly discussed. Critical qualities of PCC coating used for biomedical application including corrosion resistance, wettability and bonding strength were analyzed separately. Biological response including in vitro cell investigations and in vivo tissue response were discussed in terms of the cytocompatibility and bioactivity of PCC coating. Further investigations are proposed to develop appropriate performance evaluation measurements by combining conventional technologies and biomedical procedures. (C) 2014 Elsevier B.V. All rights reserved.