标题：Primary yolk sac tumor of the endometrium: a case report and review of the literatures
作者：Lu, Tao; Qi, Liping; Ma, Yanhui; Lu, Guojiao; Zhang, Xiaolei; Liu, Peishu
作者机构：[Lu, Tao; Qi, Liping; Ma, Yanhui; Lu, Guojiao; Zhang, Xiaolei; Liu, Peishu] Shandong Univ, Dept Obstet & Gynecol, Qilu Hosp, Jinan 250012, Shandong, P 更多
通讯作者：Zhang, XL;Liu, PS
通讯作者地址：[Zhang, XL; Liu, PS]Shandong Univ, Dept Obstet & Gynecol, Qilu Hosp, Jinan 250012, Shandong, Peoples R China.
来源：ARCHIVES OF GYNECOLOGY AND OBSTETRICS
关键词：Yolk sac tumor; Endodermal sinus tumor; alpha-Fetoprotein; Ovarian; preservation; Endocrine function preservation; Endometrium
摘要：Purpose Yolk sac tumor (YST) is a malignant tumor derived from germ cells and usually occurs in the gonads. Extra-gonadal YST is most commonly seen in the vagina of children, but rarely in the cervix, vulva and endometrium. Primary YST of endometrium was extremely rare, standard treatment was still controversial and no guideline was established so far. The aim of the present study was to provide a comprehensive understanding and systematic thought for the management of primary YST of endometrium. Methods A systematic research of the literature was conducted in Scopus, PubMed database and Cochrane Library, including case reports and case series. We summarized clinical characteristics, treatments and prognosis of all collected cases. We collected data regarding patients, serum AFP level, initial symptoms, surgical information, postoperative chemotherapy and radiotherapy. A new case was also discussed. Results We found only 26 cases have been reported previously. We reported a new case of primary endometrial YST in a 27-year-old woman, and in this case, we creatively performed bilaterally ovarian preservation and used DC (docetaxel and carboplatin) regimen of postoperative chemotherapy, we achieved a relatively good prognosis during the follow-up period of 14 months. Conclusion Primary YST of endometrium, kind of highly malignant germ cell tumors, was extremely rare, of which initial symptom is usually abnormal vaginal bleeding. Standard treatment was still controversial and no guideline was established so far. Surgery combining with postoperative chemotherapy was considered effective for treatment of primary endometrial YST. Decision on whether to preserve ovaries in young patient with early stage needs careful consideration, comprehensive preoperative assessment and full communication. Intraoperative biopsy and strict postoperative follow-up are recommended. However, standard chemotherapy regimen and feasibility of postoperative radiotherapy remains to be discussed.