标题：Red-shifted electrochemiluminescence of CdTe nanocrystals via Co2+-Doping and its spectral sensing application in near-infrared region
作者：Gao, Xuwen; Fu, Kena; Fu, Li; Wang, Huaisheng; Zhang, Bin; Zou, Guizheng
作者机构：[Gao, Xuwen; Fu, Kena; Fu, Li; Zhang, Bin; Zou, Guizheng] Shandong Univ, Sch Chem & Chem Engn, Jinan 250100, Peoples R China.; [Wang, Huaisheng] Lia 更多
通讯作者地址：[Zou, GZ]Shandong Univ, Sch Chem & Chem Engn, Jinan 250100, Peoples R China.
来源：BIOSENSORS & BIOELECTRONICS
关键词：Electrochemiluminescence; Near-infrared; Co2+-doped CdTe NCs;; Immunosensor; Human carcinoembryonic antigen
摘要：Novel optical labels for biosensing in near-infrared (NIR) region (especially between 800 and 900 nm) are arousing much attention for higher penetrating capability, less scattering and lowered autofluorescent background. Herein, a water-soluble electrochemiluminophore with effective electrochemiluminescence (ECL) around 815 nm is developed via doping dual-stabilizers-capped CdTe nanocrystals (NCs) with Co2+ species in a growth-doping way. The Co2+-doped CdTe NCs not only can preserve the highly-passivated surface states of dual-stabilizers-capped CdTe NCs, but also exhibit efficient red-shifted photoluminescence (PL) and ECL into the promising optical NIR window of 800-900 nm. A spectrum-based ultrasensitive NIR ECL immunosensor is consequently fabricated with the Co2+-doped CdTe NCs as tags for the first time, which can selectively and sensitively determine human carcinoembryonic antigen with a wide linearity range from 1 fg/mL to 10 pg/mL and a low limit of detection at 0.2 fg/mL (S/N = 3). This work opens a way to screen novel NIR electrochemiluminophore as well as to modulate the ECL performance of NCs via surface doping and engineering.