标题：Preparation of Cefquinome Nanoparticles by Using the Supercritical Antisolvent Process
作者：Xiao Kefeng; Wang Weiqiang; Hu Dedong; Hao Zhihui; Qu Yanpeng; Liu Yan
作者机构：[Xiao Kefeng; Wang Weiqiang; Qu Yanpeng; Liu Yan] Shandong Univ, Sch Mech Engn, Jinan 250061, Peoples R China.; [Xiao Kefeng; Hao Zhihui] Qingdao Ag 更多
通讯作者地址：[Wang, WQ]Shandong Univ, Sch Mech Engn, Jinan 250061, Peoples R China.
来源：JOURNAL OF NANOMATERIALS
摘要：The supercritical antisolvent process was used successfully to prepare nanoparticles of cefquinome. These particles were observed by scanning electron microscope (SEM) and their average diameter was measured by laser particle size analyzer. In the experiments, dimethyl sulfoxide (DMSO) was selected as solvent to dissolve cefquinome sulfate. It was confirmed by orthogonal experiments that the concentration of solution was the primary factor in this process followed by feeding speed of solution, precipitation pressure, and precipitation temperature. Moreover, the optimal conditions of preparing nanoparticles of cefquinome by supercritical antisolvent process were that solution concentration was 100 mg/mL, solution flow speed was 1.5 mL/min, operating pressure was 13 Mpa, and operating temperature was 33 degrees C. Confirmatory experiment was conducted under this condition. It was found that the appearance of particles was flakes and the average diameter of particles was 0.71 microns. Finally, influence law of individual factor on particle size was investigated by univariate analysis.