标题:Direct oxidative C-H alkynylation of N-carbamoyl tetrahydroisoquinolines and dihydroisoquinolines
作者:Chen, Lei; Sun, Chuanxi; Feng, Guidong; Cao, Min; Zhao, Shu-lei; Yan, Jun; Wan, Ren-zhong; Liu, Lei
作者机构:[Chen, Lei; Sun, Chuanxi; Feng, Guidong; Yan, Jun; Wan, Ren-zhong] Shandong Agr Univ, Coll Anim Sci & Vet Med, Tai An 271018, Shandong, Peoples R Chin 更多
通讯作者:Wan, RenZhong
通讯作者地址:[Wan, RZ]Shandong Agr Univ, Coll Anim Sci & Vet Med, Tai An 271018, Shandong, Peoples R China;[Liu, L]Shandong Univ, Sch Chem & Chem Engn, Jinan 25010 更多
来源:ORGANIC & BIOMOLECULAR CHEMISTRY
出版年:2018
卷:16
期:15
页码:2792-2799
DOI:10.1039/c8ob00373d
摘要:An efficient oxidative C-H alkynylation of N-carbamoyl tetrahydroisoquinolines mediated by a TEMPO oxoammonium salt has been established A variety of electronically varied N-carbamoyl tetrahydroisoquinolines reacted with a range of alkynyl potassium trifluoroborates smoothly under mild metal-free conditions Dihydroisoquinolines were also suitable components for the reaction The synthetic applicability of the method for facile access to structurally diverse bioactive molecules was further demonstrated.
收录类别:EI;SCOPUS;SCIE
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-85045850583&doi=10.1039%2fc8ob00373d&partnerID=40&md5=a876c52ea8f4dbc757227ed7205a9724
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