标题：Research and development of novel histone deacetylase inhibitors
作者机构：[Hao Fang]Institute of Medicinal Chemistry,School of Pharmaceutical Sciences,Shandong University
来源：Proceedings of the 4th CPA-RSC Symposium on Medicinal Chemistry: Epigenetics as Targets for Drug Discovery
关键词：Research and development of novel histone deacetylase inhibitors;
摘要：Histone deacetylases(HDACs),a family of enzymes involved in epigenetic modification,have been validated as promising targets for antitumor drug design.Recently we developed series of novel HDACs inhibitors(HDACIs), among which tetrahydroisoquinoline-based derivatives,1-3 N-hydroxycinnamamide-base...