标题:A bestatin-based fluorescent probe for aminopeptidase N cell imaging
作者:Hui Chen; Hui Wang; Xiao-Jun Qin; Chen Chen; Lu Feng; Lai-Zhong Chen; Lu-Pei Du; Min-Yong Li
作者机构:[Chen, H] Department of Medicinal Chemistry, School of Pharmacy, Shandong University, Jinan, 250012, China;[ Wang, H] China Pharmaceutical University 更多
通讯作者地址:[Li, MY]Shandong Univ, Sch Pharm, Key Lab Chem Biol MOE, Dept Med Chem, Jinan 250012, Peoples R China.
来源:中国化学快报(英文版)
出版年:2015
卷:26
期:5
页码:513-516
DOI:10.1016/j.cclet.2015.01.023
关键词:Aminopeptidase N;Bestatin;Cell imaging;Fluorescent probe
摘要:Aminopeptidase N (APN) is an important drug target and biomarker for various tumors. The current work characterizes a novel APN-targeted fluorescent probe (Bes-Green, 2) that manifests comparable inhibitory activity with Bestatin. This probe has capacity of tightly binding to the APN for imaging endogenous APN in living human ovarian clear cell carcinoma cells (ES-2) and has potential application in biological study of cellular APN. (C) 2015 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.
收录类别:CSCD;SCOPUS;SCIE
WOS核心被引频次:4
Scopus被引频次:5
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-84937759820&doi=10.1016%2fj.cclet.2015.01.023&partnerID=40&md5=ae440e8297944254caaac95158fa14a5
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