标题:Effect of Oral Atorvastatin on CD4(+)CD25(+) Regulatory T Cells, FoxP3 Expression, and Prognosis in Patients With ST-Segment Elevated Myocardial Infarction Before Primary Percutaneous Coronary Intervention
作者:Zhang, Dan; Wang, Shaoqin; Guan, Yuqing; Wang, Lei; Xie, Wenzhi; Li, Nan; Zhao, Peng; Su, Guohai
作者机构:[Zhang, Dan; Wang, Shaoqin; Guan, Yuqing; Wang, Lei; Xie, Wenzhi; Li, Nan; Su, Guohai] Shandong Univ, Jinan Cent Hosp, Dept Cardiol, Jinan 250013, Sha 更多
通讯作者:Su, GH
通讯作者地址:[Su, GH]Shandong Univ, Jinan Cent Hosp, Dept Cardiol, Jinan 250013, Shandong, Peoples R China.
来源:JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
出版年:2011
卷:57
期:5
页码:536-541
DOI:10.1097/FJC.0b013e318211d016
关键词:STEMI; inflammation; statins; CD4(+)CD25(+); Tregs; Foxp3
摘要:Objective: Our objective was to explore the effects of atorvastatin on changes of CD4(+)CD25(+) regulatory T cells (Tregs), FoxP3 expression in the infarct-related coronary artery, and peripheral veinous blood of patients with ST-segment elevation myocardial infarction.; Methods: We recorded 112 cases of patients with ST-segment elevation myocardial infarction who were randomly assigned to receive either atorvastatin 80 mg (n = 52) or placebo (n = 60) before primary percutaneous coronary intervention. Blood samples were obtained from the infarct-related coronary artery and peripheral vein during percutaneous coronary intervention. The proportion of CD4(+)CD25(+) Tregs, FoxP3 mRNA expression in blood and concentrations of transforming growth factor-beta and interferon-gamma in plasma of the samples were measured or detected by flow cytometry, real-time polymerase chain reaction, or enzyme-linked immunosorbent assay, respectively.; Results: In comparison with the control group, the proportions of CD4(+)CD25(+) Tregs and the mRNA level of FoxP3 and transforming growth factor-beta significantly increased; however, interferon-gamma decreased with atorvastatin therapy. In the controls, the proportions of CD4(+)CD25(+) Tregs and the mRNA level of FoxP3 and transforming growth factor-beta were significantly decreased, but the level of interferon-gamma increased more in the infarct-related coronary artery than in the peripheral vein.; Conclusion: The inhibition of CD4(+)CD25(+) Tregs in patients with ST-segment elevation myocardial infarction could be regulated with atorvastatin given before percutaneous coronary intervention.
收录类别:SCOPUS;SCIE
WOS核心被引频次:15
Scopus被引频次:11
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-79957711172&doi=10.1097%2fFJC.0b013e318211d016&partnerID=40&md5=55f4f7ca0ad73ae08782c41fff8f4c05
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