标题：HDGF: a novel jack-of-all-trades in cancer
作者：Bao, Cihang; Wang, Jianbo; Ma, Wei; Wang, Xintong; Cheng, Yufeng
作者机构：[Bao, Cihang; Wang, Jianbo; Wang, Xintong; Cheng, Yufeng] Shandong Univ, Dept Radiat Oncol, Qilu Hosp, Jinan 250012, Peoples R China.; [Ma, Wei] Nin 更多
通讯作者地址：[Cheng, YF]Shandong Univ, Dept Radiat Oncol, Qilu Hosp, 107 Wenhua Rd West, Jinan 250012, Peoples R China.
关键词：angiogenesis; apoptosis; epithelial-to-mesencyhmal transition;; hepatoma-derived growth factor; metastasis; molecular mechanisms;; prognosis; PWWP; HATH domain; serum levels; tumorigenesis
摘要：HDGF is an important regulator of a broad range of cancer cell activities and plays important roles in cancer cell transformation, apoptosis, angiogenesis and metastasis. Such a divergent influence of HDGF on cancer cell activities derives from its multiple inter- and sub-cellular localizations where it interacts with a range of different binding partners. Interestingly, high levels of HDGF could be detected in patients' serum of some cancers. This review is focused on the role of HDGF in tumorigenesis and metastasis, and provides insight for application in clinical cancer therapy as well as its clinical implications as a prognostic marker in cancer progression.