标题:A review of CXCR4/CXCL12 axis in colorectal cancer
作者:Zhi-Yu Song;Zu-Hua Gao;Xian-Jun Qu
作者机构:[Song, Z.-Y] Department of Pharmacology, School of Pharmaceutical Sciences, Shandong University, Jinan, China;[ Gao, Z.-H] Department of Pathology, Mc 更多
通讯作者:Qu, XJ(qxj@sdu.edu.cn)
通讯作者地址:[Qu, X.-J] Department of Pharmacology, School of Pharmaceutical Sciences, Shandong University, Jinan, China;
来源:Biomedicine & aging pathology
出版年:2014
卷:4
期:3
页码:285-290
DOI:10.1016/j.biomag.2014.06.001
关键词:Colorectal cancer;CXCR4/CXCL12axis;Metastasis
摘要:The chemokine CXCL12 (SDF-1) is an extracellular chemokine which binds to its cell surface receptor CXCR4. The axis of CXCL12/CXCR4 has been considered to play an important role for cancer cell migration. Recently, the aberrant expression of CXCR4 has been found during the malignancy of colorectal cancer (CRC), where it plays a crucial role in, among others, the proliferation, angiogenesis and metastatic spread. Various intracellular signal transduction cascades and effectors related to the CXCR4/CXCL12 axis have been determined, such as MAPK, PI-3K/Akt and Wnt. Currently, the potential role of CXCR4/CXCL12 as the therapeutic target for treatment of CRC has been focused. In this review, we summarized recent research on CXCL12/CXCR4 axis in the development of CRC.
收录类别:SCOPUS
Scopus被引频次:2
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-84903685520&doi=10.1016%2fj.biomag.2014.06.001&partnerID=40&md5=84227016803393748f521a4c8c7eaab2
TOP