标题:First Discovery of Novel 3-Hydroxy-quinazoline-2,4(1H,3H)-diones as Specific Anti-Vaccinia and Adenovirus Agents via \"Privileged Scaffold\" Refining Approach
作者:Dongwei Kang;Peng Zhan;Xinyong Liu;
作者机构:[Dongwei Kang;Peng Zhan;Xinyong Liu]Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceu 更多
会议名称:中国化学会第30届学术年会-第二十八分会:化学生物学
来源:中国化学会第30届学术年会摘要集-第二十八分会:化学生物学
出版年:2016
关键词:quinolinone;vaccinia;adenovirus;click chemistry;high-throughput screening
摘要:The construction of a novel series of 1,2,3-triazolyl 3-hydroxy-quinazoline-2,4(1H,3H)-diones utilizing Cu(I)-catalyzed azide-alkyne 1,3-dipolar cycloaddition(CuAAC) is described.The biological significance of the novel synthesized quinazolines was highlighted by evaluating them in vitro for antivir...
资源类型:会议论文
原文链接:http://kns.cnki.net/kns/detail/detail.aspx?FileName=ZGHY201607037210&DbName=CPFD2017
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