标题：Influence of vinyltrimethoxysilane on properties of methylene blue-loaded Silica@Octacalcium phosphate as drug delivery
作者：Li, Yadong ;Bai, Zhijie ;Wang, Baiwei ;Sun, Yanbiao ;Yang, Zhanzhong ;Li, Chengfeng
作者机构：[Li, Yadong ;Bai, Zhijie ;Wang, Baiwei ;Sun, Yanbiao ;Yang, Zhanzhong ;Li, Chengfeng ] School of Materials Science and Engineering, Shandong Universit 更多
来源：Kuei Suan Jen Hsueh Pao/Journal of the Chinese Ceramic Society
摘要：Methylene blue-loaded silica (silica-MB) particles were prepared by a modified Stöber process with MB and vinyltrimethoxysilane (A171). Silica-MB@OCP powders were obtained after the deposition of octacalcium phosphate (OCP) on the surface of silica-MB by a modified Pechini process. The addition of A171 during the sol-gel process affects the phases, constitutes and core-shell structure of samples. The addition amount of A171, core-shell structure and pH value of culture solution have effects on the release behaviors of MB, i.e., cumulative release and ratio of released MB monomers versus dimers. Unlike silica-MB, the degradation percents of silica-MB@OCP increase significantly in phosphate buffer saline and lysosome-like buffer.
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