标题：The prognostic value of immunoscore in patients with colorectal cancer: A systematic review and meta-analysis
作者：Sun, Guorui; Dong, Xiaoyuan; Tang, Xiaolong; Qu, Hui; Zhang, Hao; Zhao, Ensheng
作者机构：[Sun, Guorui; Tang, Xiaolong; Qu, Hui; Zhang, Hao; Zhao, Ensheng] Shandong Univ, Dept Gastrointestinal Surg, Qilu Hosp, Jinan, Shandong, Peoples R Chi 更多
通讯作者地址：[Dong, XY]Shandong Univ, Dept Hematol, Qilu Hosp, Jinan, Shandong, Peoples R China.
关键词：colorectal cancer; immunoscore; meta-analysis; prognosis
摘要：The tumor immune infiltrate, as recently evaluated with the immunoscore methodology, has been reported to be related to colorectal cancer (CRC) progression. Nevertheless, results varied from different studies. A meta-analysis was conducted to solve this problem. We collected data from included studies to evaluate the prognostic role of immunoscore in CRC patients on overall survival (OS) and disease-free survival (DFS). MEDLINE, EMBASE, and Cochrane libraries were searched through 30 June 2018. Hazard ratio (HR) with 95% confidence intervals (95% CI) was pooled using a random-effects model for OS and a fixed-effects model for DFS. Finally, eight studies (involving 4689 CRC cases) were identified as eligible publications. The results of the meta-analysis showed that low immunoscore was significantly correlated with poor OS (HR = 1.74, 95% CI: 1.43-2.13) and DFS (HR = 1.82, 95% CI: 1.64-2.03). The findings from most subgroup analyses were consistent with those from the overall analysis. The immunoscore could be a useful prognostic marker in patients with CRC. It is necessary to evaluate immunological markers in international multicenter studies.