标题：Undescribed C-geranylflavonoids isolated from the fruit peel of Paulownia catalpifolia T. Gong ex DY Hong with their protection on human umbilical vein endothelial cells injury induced by hydrogen peroxide
作者：Wang, Ying-Ai; Guo, Xing; Jia, Xian-Hui; Xue, Jing; Du, Hong-Fang; Du, Cheng-Lin; Tang, Wen-Zhao; Wang, Xiao-Jing; Zhao, Yun-Xue
作者机构：[Wang, Ying-Ai; Xue, Jing; Du, Hong-Fang] Univ Jinan, Shandong Acad Med Sci, Sch Med & Life Sci, Jinan 250200, Shandong, Peoples R China.; [Wang, Yi 更多
通讯作者地址：[Tang, WZ]Shandong Acad Med Sci, Inst Mat Med, Jinan 250062, Shandong, Peoples R China.
关键词：Paulownia catalpifolia; Paulowniaceae; C-geranylated flavonoids; Human; umbilical vein endothelial cells; Cell apoptosis
摘要：Six undescribed C-geranylated flavonoids, including five C-geranylflavanones named as paucatalinones F - J, one C-geranylflavonol named as paucatalinone K, along with seven known geranylated flavanones, were isolated from the fruit peel of Paulownia catalpifolia T. Gong ex D.Y. Hong. Their structures were elucidated distinctly according to their UV, IR, MS, NMR, and CD data. Among them, two compounds were substituted with unusual modified geranyl groups, namely paucatalinone F with an oxygenated cyclogeranyl substituent and paucatalinone H with a terminal pyranoid geranyl substituent. Furthermore, the protective effects on human umbilical vein endothelial cells (HUVECs) injury induced by H2O2 were evaluated, and paucatalinone F showed the most potential activity. The bioactive results suggested that the geranyl substituent may be an important factor for restraining oxidative HUVECs damage and Paulownia C-geranylated flavonoids might have the potential for preventing cardiovascular complications.