标题:Role of IL-9 and STATs in hematological malignancies ( Review)
作者:Chen, Na; Wang, Xin
作者机构:[Chen, Na; Wang, Xin] Shandong Univ, Prov Hosp, Dept Hematol, Jinan 250021, Shandong, Peoples R China.; [Wang, Xin] Shandong Univ, Sch Med, Dept Dia 更多
通讯作者:Wang, X
通讯作者地址:[Wang, X]Shandong Univ, Prov Hosp, Dept Hematol, 324 Jingwu Rd, Jinan 250021, Shandong, Peoples R China.
来源:ONCOLOGY LETTERS
出版年:2014
卷:7
期:3
页码:602-610
DOI:10.3892/ol.2013.1761
关键词:hematological malignancies; IL-9; STAT3; STAT6
摘要:Although interleukin-9 (IL-9) exhibits pleiotropic functions in the immune system, it remains a well-known cytokine in hematological malignancies. Previous cell culture and animal model studies have revealed that the Janus kinase-signal transducer and activator of transcription signaling pathway, which may be activated by a number of cytokines including IL-9, is critical in hematological malignancies. The current review summarizes the characterization of the biological activities of IL-9, highlights the clearly defined roles of the cytokine, and outlines questions with regard to the functions of IL-9 that require further exploration and their downstream signaling proteins, signal transducers and activators of transcription.
收录类别:SCOPUS;SCIE
WOS核心被引频次:4
Scopus被引频次:5
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-84892966814&doi=10.3892%2fol.2013.1761&partnerID=40&md5=b2ec820f025d5d629ef7de4da6967271
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