标题：Role of IL-9 and STATs in hematological malignancies ( Review)
作者：Chen, Na; Wang, Xin
作者机构：[Chen, Na; Wang, Xin] Shandong Univ, Prov Hosp, Dept Hematol, Jinan 250021, Shandong, Peoples R China.; [Wang, Xin] Shandong Univ, Sch Med, Dept Dia 更多
通讯作者地址：[Wang, X]Shandong Univ, Prov Hosp, Dept Hematol, 324 Jingwu Rd, Jinan 250021, Shandong, Peoples R China.
关键词：hematological malignancies; IL-9; STAT3; STAT6
摘要：Although interleukin-9 (IL-9) exhibits pleiotropic functions in the immune system, it remains a well-known cytokine in hematological malignancies. Previous cell culture and animal model studies have revealed that the Janus kinase-signal transducer and activator of transcription signaling pathway, which may be activated by a number of cytokines including IL-9, is critical in hematological malignancies. The current review summarizes the characterization of the biological activities of IL-9, highlights the clearly defined roles of the cytokine, and outlines questions with regard to the functions of IL-9 that require further exploration and their downstream signaling proteins, signal transducers and activators of transcription.