标题：Gold Nanoparticle-Induced Cell Death and Potential Applications in Nanomedicine
作者：Sun, Hainan; Jia, Jianbo; Jiang, Cuijuan; Zhai, Shumei
作者机构：[Sun, Hainan; Jia, Jianbo; Zhai, Shumei] Shandong Univ, Sch Chem & Chem Engn, Jinan 250100, Shandong, Peoples R China.; [Jia, Jianbo] Guangzhou Univ 更多
通讯作者地址：[Zhai, SM]Shandong Univ, Sch Chem & Chem Engn, Jinan 250100, Shandong, Peoples R China.
来源：INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
关键词：gold nanoparticles; cell death; proliferation; apoptosis; necrosis;; autophagy
摘要：Cell death is crucial to human health and is related to various serious diseases. Therefore, generation of new cell death regulators is urgently needed for disease treatment. Nanoparticles (NPs) are now routinely used in a variety of fields, including consumer products and medicine. Exhibiting stability and ease of decoration, gold nanoparticles (GNPs) could be used in diagnosis and disease treatment. Upon entering the human body, GNPs contact human cells in the blood, targeting organs and the immune system. This property results in the disturbance of cell function and even cell death. Therefore, GNPs may act as powerful cell death regulators. However, at present, we are far from establishing a structure-activity relationship between the physicochemical properties of GNPs and cell death, and predicting GNP-induced cell death. In this review, GNPs' size, shape, and surface properties are observed to play key roles in regulating various cell death modalities and related signaling pathways. These results could guide the design of GNPs for nanomedicine.