标题：HDAC6: Physiological function and its selective inhibitors for cancer treatment
作者： Yang, P H; Zhang, L; Zhang, Y J; Zhang, J; Xu, W F
作者机构：[Yang, P] Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Shandong University, Ji'nan, Shandong, China;[ Zhang, L] Department of 更多
通讯作者地址：Xu, W.电子邮件: email@example.com
来源：Drug Discoveries and Therapeutics
摘要：Acetylation and deacetylation of histones are important in regulating gene expression and play a key role in modification of gene transcription. Specific HDACs isoforms can be regarded as a target for cancer therapy avoiding side-effects, HDAC6 with a unique physiological function and structure has become a hot issue recently. The unique isoform HDAC6 is involved in tumorigenesis, development and metastasis through tubulin, HSP90, invasin and ubiquitin-protein. Here we review the structure elements, biological function, and recent selective inhibitors of HDAC6, and study the structure-activity and structureselectivity relationship.