标题:HDAC6: Physiological function and its selective inhibitors for cancer treatment
作者: Yang, P H; Zhang, L; Zhang, Y J; Zhang, J; Xu, W F
作者机构:[Yang, P] Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Shandong University, Ji'nan, Shandong, China;[ Zhang, L] Department of 更多
通讯作者地址:Xu, W.电子邮件: xuwenf@sdu.edu.cn
来源:Drug Discoveries and Therapeutics
出版年:2013
卷:7
期:6
DOI:10.5582/ddt.2013.v7.6.233
摘要:Acetylation and deacetylation of histones are important in regulating gene expression and play a key role in modification of gene transcription. Specific HDACs isoforms can be regarded as a target for cancer therapy avoiding side-effects, HDAC6 with a unique physiological function and structure has become a hot issue recently. The unique isoform HDAC6 is involved in tumorigenesis, development and metastasis through tubulin, HSP90, invasin and ubiquitin-protein. Here we review the structure elements, biological function, and recent selective inhibitors of HDAC6, and study the structure-activity and structureselectivity relationship.
收录类别:SCOPUS;
Scopus被引频次:19
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-84899791602&doi=10.5582%2fddt.2013.v7.6.233&partnerID=40&md5=1e139aced55f79bab9e3b19fe8dd8482
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