标题:Trps1 is associated with the multidrug resistance of osteosarcoma by regulating MDR1 gene expression
作者:Jia,M.;Hu,J.;Li,W.;Su,P.;Zhang,H.;Zhang,X.;Zhou,G.
作者机构:Department of Pathology and Pathophysiology, Shandong University School of Medicine, 44#, Wenhua Xi;Department of Pathology and
通讯作者:Zhou, GY
通讯作者地址:[Zhou, GY]Shandong Univ, Sch Med, Dept Pathol & Pathophysiol, 44 Wenhua Xi Rd, Jinan 250012, Shandong, Peoples R China.
来源:FEBS Letters: For the Rapid Publication of Short Reports in Biochemistry, Biophysics and Molecular Biology
出版年:2014
卷:588
期:5
页码:801-810
DOI:10.1016/j.febslet.2014.01.041
关键词:Chemotherapy;CHIP;MDR1;Multidrug resistance;Osteosarcoma;P-gp;TGFbeta-1;TRPS1
摘要:Multidrug resistance (MDR) is a significant clinical problem in the chemotherapy of osteosarcoma and has been linked to the cellular expression of several multidrug-efflux transporters such as MDR1/P-gp. Our inhibition of the transcription factor Trps1 led to repression of MDR1/P-gp while its overexpression resulted in upregulation of MDR1/P-gp. Flow cytometric analysis suggested Trps1 increased the release of several anti-cancer drugs, thus decreasing their accumulation. Immunohistochemical analysis of clinical samples indicated that the expression of Trps1 directly correlated with MDR1/P-gp. Trps1 inhibited TGFbeta-1 and directly bound to the MDR1 promoter. Our data demonstrate a role for Trps1 in the regulation of MDR1 expression in osteosarcoma.
收录类别:SCIE
WOS核心被引频次:7
资源类型:期刊论文
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