标题：The Roles of CD147 and/or Cyclophilin A in Kidney Diseases
作者：Qu, Xin; Wang, Chunting; Zhang, Jicheng; Qie, Guoqiang; Zhou, Jianxin
作者机构：[Qu, Xin; Wang, Chunting; Zhang, Jicheng; Qie, Guoqiang] Shandong Univ, Shandong Prov Hosp, Dept Crit Care Med, Jinan 250021, Peoples R China.; [Qu, 更多
通讯作者地址：[Zhou, JX]Capital Med Univ, Beijing Tiantan Hosp, Dept Crit Care Med, 6 Tiantan Xili, Beijing 100050, Peoples R China.
来源：MEDIATORS OF INFLAMMATION
摘要：CD147 is a widely expressed integral plasma membrane glycoprotein and has been involved in a variety of physiological and pathological activities in combination with different partners, including cyclophilins, caveolin-1, monocarboxylate transporters, and integrins. Recent data demonstrate that both CyPA and CD147 significantly contribute to renal inflammation, acute kidney injury, renal fibrosis, and renal cell carcinoma. Here we review the current understanding of cyclophilin A and CD147 expression and functions in kidney diseases and potential implications for treatment of kidney diseases.