标题:miR-590 accelerates lung adenocarcinoma migration and invasion through directly suppressing functional target OLFM4
作者:Liu, Yanhong; Wang, Feng; Xu, Peng
作者机构:[Liu, Yanhong; Wang, Feng] First Peoples Hosp Shangqiu, Dept Resp Med, Shangqiu 476100, Henan, Peoples R China.; [Xu, Peng] Shandong Univ, Jinan Cen 更多
通讯作者:Xu, P
通讯作者地址:[Xu, P]Shandong Univ, Jinan Cent Hosp, Dept Thorac Surg, 105 Jiefang Rd, Jinan 250013, Shandong, Peoples R China.
来源:BIOMEDICINE & PHARMACOTHERAPY
出版年:2017
卷:86
页码:466-474
DOI:10.1016/j.biopha.2016.12.003
关键词:microRNA; miR-590; OLFM4; Lung adenocarcinoma; Metastasis
摘要:MicroRNA-590 (miR-590) shows oncogenic functions in various tumor types, but little is known about biological functions of miR-590 in lung adenocarcinoma. In this study, we observe that miR-590 is not only overexpressed in lung adenocarcinoma tissues and metastatic lymph nodes, but also significantly increased in lung adenocarcinoma cell lines. Moreover, gain-of-function and loss-of-function studies show miR-590 serve as a tumor suppressor regulating lung adenocarcinoma cells migration and invasion. Furthermore, OLFM4 is proved to as a functional target for miR-590 to regulate lung adenocarcinoma cells migration and invasion. In conclusion, miR-590 regulates lung adenocarcinoma metastasis through directly modulating functional target OLFM4. (C) 2016 Elsevier Masson SAS. All rights reserved.
收录类别:SCOPUS;SCIE
WOS核心被引频次:4
Scopus被引频次:4
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-85007227235&doi=10.1016%2fj.biopha.2016.12.003&partnerID=40&md5=db706f3e87e5907704d09c18a60d9cc7
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