标题：Stent insertion with high-intensity focused ultrasound ablation for distal biliary obstruction secondary to pancreatic carcinoma
作者：Yang S.-Y.; Liu F.; Liu Y.; Xia F.-F.; Fu Y.-F.
作者机构：[Yang, S.-Y] Department of Gynaecology and Obstetrics, Qilu Hospital of Shandong University, Jinan, China;[ Liu, F] Department of Gynaecology and Obst 更多
通讯作者地址：[Yang, S.-Y] Department of Gynaecology and Obstetrics, Qilu Hospital of Shandong University, 107 West Wenhua Road, China;
来源：Medicine (United States)
关键词：high-intensity focused ultrasound ablation; pancreatic carcinoma; stent
摘要：We determined the clinical effectiveness and long-term outcomes in patients with distal biliary obstruction (DBO) secondary to pancreatic carcinoma (PC) who were treated by self-expanded metallic stent (SEMS) insertion with or without high-intensity focused ultrasound (HIFU) ablation.From January 2014 to December 2018, consecutive patients with DBO secondary to PC underwent SEMS insertion with or without HIFU ablation in our center. The long-term outcomes were compared between the 2 groups.During the included period, 75 patients underwent SEMS insertion with (n=34) or without (n=41) HIFU ablation in our center. SEMS insertion was successfully performed in all patients. Liver function was significantly improved after SEMS insertion in both groups. An average of 2.9 HIFU treatment sessions per patient were performed. Twenty patients (stent + HIFU group: 7; stent-only group: 13) experienced stent dysfunction (P=.278). The clinical response rate to HIFU ablation was 79.4%. The median stent patency was significantly longer in the stent with HIFU group than in the stent-only group (175 vs 118 days, P=.005). The median survival was significantly longer in the stent with HIFU group compared with the stent-only group (211 versus 136 days, P=.004). An Eastern Cooperative Oncology Group (ECOG) Performance Status of 3 (hazard ratio: 0.300; P=.002) and subsequent HIFU ablation (hazard ratio: 0.508; P=.005) were associated with prolonged survival.HIFU ablation following stent insertion can prolong the stent patency and survival for patients with DBO secondary to PC. © 2020 Lippincott Williams and Wilkins. All rights reserved.