标题：Altered hippocampal GABA and glutamate levels and uncoupling from functional connectivity in multiple sclerosis
作者：Gao, Fei; Yin, Xuntao; Edden, Richard A. E.; Evans, Alan C.; Xu, Junhai; Cao, Guanmei; Li, Honghao; Li, Muwei; Zhao, Bin; Wang, Jian 更多 作者机构：[Gao, Fei; Cao, Guanmei; Zhao, Bin; Wang, Guangbin] Shandong Univ, Shandong Med Imaging Res Inst, Jing Wu Rd 324, Jinan 250021, Shandong, Peoples R Ch 更多
通讯作者地址：[Wang, GB]Shandong Univ, Shandong Med Imaging Res Inst, Jing Wu Rd 324, Jinan 250021, Shandong, Peoples R China.
关键词：functional connectivity; gamma-aminobutyric acid; glutamate;; hippocampus; multiple sclerosis
摘要：There is growing evidence for dysfunctional glutamatergic excitation and/or gamma-aminobutyric acid (GABA)ergic inhibition in patients with multiple sclerosis (MS). Cognitive impairment may occur during the early stages of MS and hippocampal abnormalities have been suggested as biomarkers. However, researchers have not clearly determined whether changes in hippocampal GABA and glutamate (Glu) levels are associated with cognitive impairment and aberrant neural activity in patients with MS. We used magnetic resonance spectroscopy to measure GABA+ and Glu levels in the left hippocampal region of 29 patients with relapsing-remitting MS and 29 healthy controls (HCs). Resting-state functional connectivity (FC) with the hippocampus was also examined. Compared to HCs, patients exhibited significantly lower GABA+ and Glu levels, which were associated with verbal and visuospatial memory deficits, respectively. Patients also showed decreased FC strengths between the hippocampus and several cortical regions, which are located within the default mode network. Moreover, hippocampal GABA+ levels and Glu/GABA+ ratios correlated with the FC strengths in HCs but not in patients with MS. This study describes a novel method for investigating the complex relationships among excitatory/inhibitory neurotransmitters, brain connectivity and cognition in health and disease. Strategies that modulate Glu and GABA neurotransmission may represent new therapeutic treatments for patients with MS.