标题：Enabling Anticancer Therapeutics by Nanoparticle Carriers: The Delivery of Paclitaxel
作者：Liu, Yongjin; Zhang, Bin; Yan, Bing
作者机构：[Liu, Yongjin; Zhang, Bin; Yan, Bing] Shandong Univ, Sch Chem & Chem Engn, Jinan 250100, Peoples R China.; [Yan, Bing] St Jude Childrens Hosp, Memph 更多
通讯作者地址：[Yan, B]Shandong Univ, Sch Chem & Chem Engn, Jinan 250100, Peoples R China.
来源：INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
关键词：nanomaterials; anticancer drugs; paclitaxel; drug carrier; drug delivery
摘要：Anticancer drugs, such as paclitaxel (PTX), are indispensable for the treatment of a variety of malignancies. However, the application of most drugs is greatly limited by the low water solubility, poor permeability, or high efflux from cells. Nanoparticles have been widely investigated to enable drug delivery due to their low toxicity, sustained drug release, molecular targeting, and additional therapeutic and imaging functions. This review takes paclitaxel as an example and compares different nanoparticle-based delivery systems for their effectiveness in cancer chemotherapy.