标题：Roles of galectin-3 in metabolic disorders and tumor cell metabolism
作者：Li, Ying-Shuang; Li, Xiao-Tong; Yu, Lu-Gang; Wang, Lei; Shi, Zhao-Yu; Guo, Xiu-Li
作者机构：[Li, Ying-Shuang; Li, Xiao-Tong; Wang, Lei; Shi, Zhao-Yu; Guo, Xiu-Li] Shandong Univ, Sch Pharmaceut Sci, Minist Educ, Dept Pharmacol,Key Lab Chem Bio 更多
通讯作者地址：[Guo, XL]Shandong Univ, Sch Pharmaceut Sci, Dept Pharmacol, 44 Wen Hua Xi Rd, Jinan 250012, Peoples R China.
来源：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
关键词：Galectin-3; Metabolic disorders; Tumor metabolism
摘要：The galactoside-binding protein galectin-3 is commonly overexpressed by cancer cells and promotes cancer progression and metastasis. Over the past few years, evidence has emerged that galectin-3 is also overexpressed in several metabolic malfunction conditions such as diabetes, obesity and atherosclerosis and is involved in the regulation of the occurrence and development of these diseases. Recently, Galectin-3 expression is shown also to be associated with glycolysis and mitochondrial metabolism in tumors, and promotes tumor metabolic reprogramming for their adaption to the microenvironment stress imposed by oxygen and nutrients deprivation. This brief review summarizes the current understanding of the roles and actions of galectin-3 in these metabolic diseases and in tumor metabolism. (C) 2019 Elsevier B.V. All rights reserved.