标题：Progress in miRNA Detection Using Graphene Material-Based Biosensors
作者：Zhang, Congcong; Miao, Pei; Sun, Mingyuan; Yan, Mei; Liu, Hong
作者机构：[Zhang, Congcong; Sun, Mingyuan; Liu, Hong] Univ Jinan, Inst Adv Interdisciplinary Res, Collaborat Innovat Ctr Technol & Equipment Biol D, Jinan 25001 更多
通讯作者：Zhang, CC;Liu, H;Liu, H
通讯作者地址：[Zhang, CC; Liu, H]Univ Jinan, Inst Adv Interdisciplinary Res, Collaborat Innovat Ctr Technol & Equipment Biol D, Jinan 250011, Shandong, Peoples R Ch 更多
关键词：electrochemical biosensors; graphene and its derivatives; miRNA; detection; optical biosensors; supramolecular nanoassemblies
摘要：MicroRNAs (miRNAs) are short, endogenous, noncoding RNAs that play critical roles in physiologic and pathologic processes and are vital biomarkers for several disease diagnostics and therapeutics. Therefore, rapid, low-cost, sensitive, and selective detection of miRNAs is of paramount importance and has aroused increasing attention in the field of medical research. Among the various reported miRNA sensors, devices based on graphene and its derivatives, which form functional supramolecular nanoassemblies of pi-conjugated molecules, have been revealed to have great potential due to their extraordinary electrical, chemical, optical, mechanical, and structural properties. This Review critically and comprehensively summarizes the recent progress in miRNA detection based on graphene and its derivative materials, with an emphasis on i) the underlying working principles of these types of sensors, and the unique roles and advantages of graphene materials; ii) state-of-the-art protocols recently developed for high-performance miRNA sensing, including representative examples; and iii) perspectives and current challenges for graphene sensors. This Review intends to provide readers with a deep understanding of the design and future of miRNA detection devices.