标题：Association between plasminogen activator inhibitor gene polymorphisms and osteonecrosis of the femoral head susceptibility: A case-control study
作者：Li, Yi; Liu, Feng-Xia; Yuan, Chao; Meng, Lingguo
作者机构：[Li, Yi] Shandong Univ, Shandong Prov Hosp, Dept Joint Surg, Jinan, Shandong, Peoples R China.; [Liu, Feng-Xia] Juye Cty Hosp Tradit Chinese Med, Cl 更多
通讯作者地址：[Meng, LG]Taishan Med Univ, Affiliated Hosp, Tai An, Shandong, Peoples R China.
关键词：haplotype; osteonecrosis of the femoral head; PAI-1; polymorphisms
摘要：This study aimed to analyze the correlation of the plasminogen activator inhibitor (PAI-1) gene polymorphisms (rs6092 and rs7242) with susceptibility of osteonecrosis of the femoral head (ONFH).This case-control study included 106 ONFH patients and 151 healthy controls. PAI-1 polymorphisms were genotyped by polymerase chain reaction (PCR) with direct sequencing. The genotype distribution of polymorphism in the control group was checked with the status of Hardy-Weinberg equilibrium (HWE). The (2) test was applied to compare the genotypes of polymorphisms between the case and control groups. The association intensity between PAI-1 polymorphisms and ONFH risk was estimated by odds ratios (ORs) and 95% confidence intervals (95% CI). The linkage disequilibrium of PAI-1 polymorphisms was analyzed by Haploview.We found that the genotypes and alleles of PAI-1 rs6092 and rs7242 polymorphisms had no obvious association with the risk of ONFH (P>.05). But the strong linkage disequilibrium existed between rs6092 and rs7242 polymorphisms and haplotype G-T was significantly associated with the decreased risk of ONFH occurrence (OR=0.666, 95%CI=0.445-0.998).PAI-1 rs6092 and rs7242 polymorphisms are not associated with ONFH development, but haplotype G-T may be a protective factor of ONFH.