标题：Vascular endothelial growth factor C expression is closely correlated with lymph node recurrence and poor prognosis in patients with early stage cervical cancer
作者机构：[DeMei, M] Department of Obstetrics and Gynaecology, The Second Hospital of Shandong University, Jinan, Shandong, China;[ XiangXin, L] Department of H 更多
通讯作者地址：[Zhu, L]Shandong Univ, Hosp 2, Dept Obstet & Gynaecol, North Pk Ave 247, Jinan 250033, Shandong, Peoples R China.
来源：The Journal of international medical research
关键词：Cervical cancer;lymph node recurrence;prognosis;vascular endothelial growth factor-C
摘要：ObjectivesTo detect vascular endothelial growth factor (VEGF)-C mRNA expression in surgically resected tissues of \'pathologic N0\' (pN0) cervical cancer; to investigate the relevance of VEGF-C mRNA expression to clinicopathological factors, lymph node recurrence and prognosis in early stage cervical cancer.MethodsPatients with pN0 cervical cancer who successfully underwent radical hysterectomy with bilateral adnexectomy and bilateral pelvic lymphadenectomy were enrolled sequentially into this retrospective study. Reverse transcriptase-polymerase chain reaction (RT-PCR) was performed to detect VEGF-C mRNA.ResultsSeventy-eight patients entered the study. VEGF-C mRNA was detected in 35 (44.87%) patients and was significantly correlated with tumour differentiation. VEGF-C mRNA expression was significantly associated with lymph node recurrence and poor overall survival 5 years after surgery. Multivariate analysis confirmed that VEGF-C mRNA expression was an independent predictor for lymph node recurrence and unfavourable overall survival.ConclusionsThese findings indicate that detection of VEGF-C mRNA has clinical potential as a predictor for identifying patients with pN0 cervical cancer at high risk of lymph node recurrence and poor prognosis.