标题：RETRACTED: Insulin-like growth factor 1 promotes growth of gastric cancer by inhibiting foxo1 nuclear retention (Retracted article. See April, 2017)
作者：Li, Shuangling; Lei, Xiaofei; Zhang, Jianna; Yang, Hongli; Liu, Jiyong; Xu, Changqing
作者机构：[Li, Shuangling; Lei, Xiaofei; Zhang, Jianna; Yang, Hongli; Xu, Changqing] Shandong Univ, Dept Gastroenterol, Shandong Prov Qianfoshan Hosp, Jinan 250 更多
通讯作者地址：[Xu, CQ]Shandong Univ, Dept Gastroenterol, Shandong Prov Qianfoshan Hosp, 16766 Jingshi Rd, Jinan 250014, Peoples R China.
关键词：Gastric cancer; Insulin-like growth factor 1 (IGF-1); Akt; mTOR; FoxO1;; Cancer growth
摘要：Gastric cancer (GC) is the fourth most common malignant human cancer. So far, the molecular mechanisms underlying the tumorigenesis of GC are not completely understood. Here, we reported significantly higher levels of serum insulin-like growth factor (IGF)-1 in GC patients and significantly higher levels of phosphorylated IGF-1 receptor (IGF-1R) in the GC specimen. Moreover, IGF-1 induced phosphorylation of IGF-1R and then phosphorylation of its downstream factor Akt in the GC cells. Further, IGF-1/Akt-induced forkhead box protein O1 (FoxO1) nuclear exclusion, but not IGF-1/Akt-induced mTOR phosphorylation, was essential for the augment in GC cell growth. Together, IGF-1/Akt/FoxO1 regulatory machinery appears to be a previously unappreciated signaling axis involved in the carcinogenesis of GC.