标题：Two new triterpenoids from the fungus Diplodia cupressi
作者：Liu X.-Y.; Wang X.-L.; Shen T.; Ren D.-M.; Lou H.-X.; Wang X.-N.
作者机构：[Liu, X.-Y] Key Laboratory of Chemical Biology (Ministry of Education) Department of Natural Product Chemistry School of Pharmaceutical Sciences, Shan 更多
通讯作者地址：[Wang, X.-N] Key Laboratory of Chemical Biology (Ministry of Education) Department of Natural Product Chemistry School of Pharmaceutical Sciences, Sha 更多
来源：Natural Product Research
关键词：Cytotoxic activity; Diplodia cupressi; Polytrchum commune; Triterpenoids
摘要：One new pentanortriterpenoid, 23,24,25,26,27-pentanorlanost-7,9(11)-dien-3β,22-diol (1), one new triterpenoid, lanost-8-en-3β,22S,23S-triol (2), together with the known triterpenoid, 23,24,25,26,27-pentanorlanost-8-en-3β,22-diol (3), were obtained from culture of the fungus Diplodia cupressi associated with the moss Polytrichum commune. The structures of the new compounds were elucidated by extensive spectroscopic techniques including HR-ESIMS and 1 D and 2 D NMR experiments. The cytotoxicity of these compounds against human cancer cell lines (A549, Hep G2, Hepa 1c1c7, and Hela) was evaluated and compound 2 exhibited weak inhibitory activity with IC 50 value of 35.0 ± 2.3 μM against the proliferation of the Hepa 1c1c7 cells. © 2019, © 2019 Informa UK Limited, trading as Taylor & Francis Group.