标题:TPH2 Gene Polymorphisms and Major Depression - A Meta-Analysis
作者:Gao, Jin; Pan, Zhenglun; Jiao, Zhian; Li, Feng; Zhao, Guoqing; Wei, Qianqian; Pan, Fang; Evangelou, Evangelos
作者机构:[Gao, Jin; Pan, Fang] Shandong Univ, Sch Med, Dept Med Psychol, Jinan, Shandong, Peoples R China.; [Gao, Jin; Jiao, Zhian; Zhao, Guoqing; Wei, Qianq 更多
通讯作者:Gao, J
通讯作者地址:[Gao, J]Shandong Univ, Sch Med, Dept Med Psychol, Jinan, Shandong, Peoples R China.
来源:PLOS ONE
出版年:2012
卷:7
期:5
DOI:10.1371/journal.pone.0036721
摘要:Background: Tryptophan hydroxylase-2 (TPH2) is the rate-limiting enzyme in the synthetic pathway for brain serotonin and is considered key factor for maintaining normal serotonin transmission in the central neuron system (CNS). Gene-disease association studies have reported a relationship between TPH2 and major depressive disorder (MDD) in different populations, however subsequent studies have produced contradictory results.; Objectives: We performed a systematic overview and a meta-analysis with all available data up-to-date.; Methods: We scrutinized PubMed, Embase, HuGNet and China National Knowledge Infrastructure (CNKI) and last update was held on October 2011. We also searched the manuscripts and the supplementary documents of the published genome-wide association studies in the field. Effect sizes of independent loci that have been studied in more than 3 articles were synthesized using fixed and random effects models.; Results: We found 27 eligible articles that studied a total of 74 single nucleotide polymorphisms (SNPs). Finally, 12 independent loci were included in the meta-analysis. The synthesis of the data shown that two SNPs (rs4570625 and rs17110747) were associated with MDD using fixed effects models. SNP rs4570625 had low heterogeneity and remained significant using the more conservative random effects calculations with a summary OR = 0.83 (95% CI: 0.73-0.96).; Conclusion: The current study identified a SNP (rs4570625) with strong epidemiological credibility; however more studies are required to provide robust evidence for other weak associations.
收录类别:SCOPUS;SCIE
WOS核心被引频次:38
Scopus被引频次:45
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-84861661993&doi=10.1371%2fjournal.pone.0036721&partnerID=40&md5=f420435963083b5ee60dcbe0443cb112
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