标题:Association of CYP17A1 gene-34T/C polymorphism with polycystic ovary syndrome in Han Chinese population
作者:Li, Li; Gu, Zhen-Peng; Bo, Qi-Mei; Wang, Dong; Yang, Xing-Sheng; Cai, Guo-Hua
作者机构:[Li, Li; Yang, Xing-Sheng] Shandong Univ, Sch Med, Jinan 250100, Shandong, Peoples R China.; [Li, Li; Gu, Zhen-Peng; Bo, Qi-Mei] Binzhou Med Coll, A 更多
通讯作者:Cai, GH
通讯作者地址:[Cai, GH]Nanking Med Univ, Affiliated Hosp 1, Nanjing 210036, Jiangsu, Peoples R China.
来源:GYNECOLOGICAL ENDOCRINOLOGY
出版年:2015
卷:31
期:1
页码:40-43
DOI:10.3109/09513590.2014.947948
关键词:CYP17A1; polycystic ovary syndrome; SNP; testosterone
摘要:Purpose: To investigate the influence of the cytochrome P450 17 alpha (CYP17A1) gene -34T/C polymorphism in the pathogenesis of polycystic ovary syndrome (PCOS) in Han Chinese population.; Methods: Three-hundred eighteen patients with PCOS and 306 controls were recruited and the CYP17A1 -34T/C polymorphism was genotyped using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Furthermore, the relationship of CYP17A1 -34T/C polymorphism and clinical feature parameters of PCOS patients was also analyzed.; Results: The prevalence rates of CYP17A1 genotype TT, TC and CC were 49.69%, 43.71% and 6.6% in the case group and those were 44.77%, 46.08% and 9.15% in the control group. The frequencies of CYP17A1 T and C alleles were 71.54% and 28.46% in the case group, and those were 67.81% and 32.19% in the control group. Neither the genotypic nor the allelic distribution was significantly different between the cases and controls. However, the PCOS patients with the genotype of CC had significantly higher total testosterone levels and Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) than those with the genotype of TT or TC.; Conclusions: The CYP17A1 gene -34T/C polymorphism might not be directly correlated with the PCOS, but might influence PCOS via the association of testosterone level and the HOMA-IR.
收录类别:SCOPUS;SCIE
WOS核心被引频次:3
Scopus被引频次:3
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-84917732006&doi=10.3109%2f09513590.2014.947948&partnerID=40&md5=a4915858f9647628ebe9c4913aebbc77
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