标题：Antimicrobial and molecular interaction studies on derivatives of curcumin against Streptococcus pneumoniae which caused pneumonia
作者：Li, Liang-Mei; Li, Jun; Zhang, Xiu-Ying
作者机构：[Li, Liang-Mei] Zhangqiu Hosp Tradit Chinese Med, Dept Resp Med, Zhangqiu 250200, Shandong, Peoples R China.; [Li, Jun] Shandong Univ, Jinan Cent Ho 更多
通讯作者地址：[Zhang, XY]Shandong Univ, Qilu Hosp, Dept Rehabil, Jinan 250100, Shandong, Peoples R China.
来源：ELECTRONIC JOURNAL OF BIOTECHNOLOGY
关键词：Antimicrobial; Curcumin; MIC; Molecular docking; Penicillin-resistant
摘要：Background: The antimicrobial properties and molecular interaction analysis of curcumin and its derivatives against three different strains of Streptococcus pneumoniae (Penicillin-susceptible, Penicillin-intermediate and Penicillin-resistant) are studied.; Results: These properties were analyzed based on the measurement of the inhibition zone, minimum inhibitory concentration (MIC), and rate of kill revealed that curcumin monoglucoside, curcumin diglucoside and curcumin possessed strong antimicrobial properties even on the Penicillin-resistant strains. Additionally, the molecular docking simulation analyses against Penicillin Binding Protein of S. pneumoniae also confirm that these compounds docked at the active site of the enzyme. Further, the molecular dynamics simulation validates the conformational stability of the docked ligand-protein complexes in the dynamic environment.; Conclusion: curcumin monoglucoside, curcumin diglucoside and curcumin can be prescribed for treatment against Penicillin-resistant S. pneumoniae. (C) 2015 Pontificia Universidad Catolica de Valparaiso. Production and hosting by Elsevier B.V. All rights reserved.