标题:Verification of a ZBTB16 variant in polycystic ovary syndrome patients
作者:Yang J.; Zhao R.; Li L.; Li G.; Yang P.; Ma J.; Zhao S.; Zhao H.
作者机构:[Yang, J] Center for Reproductive Medicine, Cheeloo College of Medicine, Shandong University, Jinan, China, National Research Center for Assisted Repr 更多
通讯作者:Zhao, S(zsg0108@126.com)
通讯作者地址:[Zhao, S] Center for Reproductive Medicine, Cheeloo College of Medicine, Shandong UniversityChina;
来源:Reproductive BioMedicine Online
出版年:2020
卷:41
期:4
页码:724-728
DOI:10.1016/j.rbmo.2020.05.005
关键词:Polycystic ovary syndrome; Single nucleotide polymorphism; ZBTB16
摘要:Research question: This study investigated whether rs1784692 is a risk factor for polycystic ovary syndrome (PCOS) in Han Chinese women. Design: A case-control study was conducted in Han Chinese women, involving 526 PCOS patients and 522 control participants. A TaqMan MGB probe assay was used to genotype the variant rs1784692. Dominant and additive models were employed for genotype–phenotype association analysis in the PCOS and control samples. Results: The minor allele C of rs1784692 is protective against PCOS (odds ratio [OR] 0.556, 95% confidence interval [CI] 0.408–0.759, P = 1.83 × 10–4), even after adjustment for body mass index (BMI) and age (ORadj 0.539, 95% CI 0.391–0.743, Padj= 1.62 × 10–4). Genotype–phenotype analysis of the dominant model showed that mean BMI in the CC+CT group was higher than in the TT group in the PCOS group (27.12 ± 5.82 versus 24.57 ± 4.52, P = 1.0 × 10–3), but not in the control groups, indicating that the minor allele C of rs1784692 associates with BMI in women with PCOS. The mean LH (luteinizing hormone) concentration in the CC+CT group was lower than in the TT group in PCOS and control participants (9.33 ± 5.08 versus 10.93 ± 5.91, P = 0.036; 4.39 ± 1.66 versus 4.89 ± 2.07, P = 0.021). Genotype–phenotype analysis of additive model showed that mean BMI in TC group was higher than in the TT group in PCOS patients compared with control participants (27.14 ± 5.81 versus 24.57 ± 4.52, P = 3.06 × 10–3). Conclusions: The SNP rs1784692 in gene ZBTB16 is protective against PCOS but is associated with increased BMI in Han Chinese women with PCOS. © 2020 Reproductive Healthcare Ltd.
收录类别:SCOPUS
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-85089509524&doi=10.1016%2fj.rbmo.2020.05.005&partnerID=40&md5=d287a4159c7873afb761510631bdae8f
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