标题:Novel leucine ureido derivatives as inhibitors of aminopeptidase N (APN)
作者:Ma,C.;Jin,K.;Cao,J.;Zhang,L.;Li,X.;Xu,W.
作者机构:[Ma, C] Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Shandong University 44, West Culture Road, Jinan 250012, China;[ Jin, K] 更多
通讯作者:Xu, WF
通讯作者地址:[Xu, WF]Shandong Univ 44, Sch Pharmaceut Sci, Dept Med Chem, West Culture Rd, Jinan 250012, Peoples R China.
来源:Bioorganic and medicinal chemistry
出版年:2013
卷:21
期:7
页码:1621-1627
DOI:10.1016/j.bmc.2013.01.068
关键词:Aminopeptidase N;Inhibitors;Leucine ureido derivatives;Synthesis
摘要:Aminopeptidase N (APN/CD13) over expressed on tumor cells, plays a critical role in tumor invasion, metastasis, and tumor angiogenesis. Here we described the design, synthesis and preliminary activity studies of novel leucine ureido derivatives as aminopeptidase N (APN/CD13) inhibitors. The results showed that compound 8c had the most potent inhibitory activity against APN with the IC 50 value to 0.06 ± 0.041 μM, which could be used for further anticancer agent research.
收录类别:SCOPUS;SCIE
WOS核心被引频次:8
Scopus被引频次:8
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-84875218168&doi=10.1016%2fj.bmc.2013.01.068&partnerID=40&md5=9b1927b6ae1402a8c893b31d805c53f7
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